Potent non-peptide fibrinogen receptor antagonists which present an alternative pharmacophore

J Med Chem. 1995 Jan 6;38(1):9-12. doi: 10.1021/jm00001a003.

Authors

T W Ku¹, W H Miller, W E Bondinell, K F Erhard, R M Keenan, A J Nichols, C E Peishoff, J M Samanen, A S Wong, W F Huffman

Affiliation

¹ Research and Development Division, SmithKline Beecham Pharmaceuticals, King of Prussia, Pennsylvania 19406.

PMID: 7837245
DOI: 10.1021/jm00001a003

No abstract available

MeSH terms

Amino Acid Sequence
Benzodiazepines / chemical synthesis*
Benzodiazepines / pharmacology*
Benzodiazepinones / chemical synthesis*
Benzodiazepinones / pharmacology*
Humans
Models, Molecular
Molecular Sequence Data
Oligopeptides / pharmacology
Peptides, Cyclic / pharmacology
Platelet Aggregation / drug effects
Platelet Membrane Glycoproteins / antagonists & inhibitors*
Protein Conformation

Substances

7-((4-guanidinophenyl)aminocarbonyl)-3-oxo-4-phenethyl-1,4-benzodiazepine-2-acetic acid
Benzodiazepinones
Oligopeptides
Peptides, Cyclic
Platelet Membrane Glycoproteins
Benzodiazepines
arginyl-glycyl-aspartic acid